Grant✓ Small businesses may apply
NIH Director’s Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional)
National Institutes of Health
Program funding
$8,000,000
- Opportunity #
- RFA-RM-27-003
- Agency
- National Institutes of Health
- ALN (CFDA)
- 93.310
- Status
- posted
- Posted
- Jun 29, 2026
- Closes
- Sep 3, 2026
- Funding instrument
- Grant
- Category
- Health
- Cost sharing required
- No
Who can apply
- •Private institutions of higher education
- •City or township governments
- •Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- •Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- •For profit organizations other than small businesses
- •Public housing authorities/Indian housing authorities
- •Native American tribal organizations (other than Federally recognized tribal governments)
- •County governments
- •Small businesses
- •State governments
- •Others (see text field entitled "Additional Information on Eligibility" for clarification)
- •Native American tribal governments (Federally recognized)
- •Special district governments
- •Independent school districts
- •Public and State controlled institutions of higher education
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
Synopsis
The NIH Director"s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome; topics may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director"s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) program of the NIH Common Fund.
Contact
National Institutes of Health · Transformative_Awards@mail.nih.gov