Grant✓ Small businesses may apply
Validation Center for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U54 Clinical Trials Not Allowed)
National Institutes of Health
Award ceiling
$2,000,000
Program funding
$2,700,000
- Opportunity #
- RFA-RM-27-014
- Agency
- National Institutes of Health
- ALN (CFDA)
- 93.310
- Status
- posted
- Posted
- Jun 30, 2026
- Closes
- Oct 2, 2026
- Funding instrument
- Cooperative Agreement
- Category
- Health
- Cost sharing required
- No
Who can apply
- •Others (see text field entitled "Additional Information on Eligibility" for clarification)
- •Special district governments
- •State governments
- •For profit organizations other than small businesses
- •Public and State controlled institutions of higher education
- •Small businesses
- •Native American tribal organizations (other than Federally recognized tribal governments)
- •Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
- •Native American tribal governments (Federally recognized)
- •Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
- •City or township governments
- •Independent school districts
- •Public housing authorities/Indian housing authorities
- •Private institutions of higher education
- •County governments
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Synopsis
The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges. The purpose of this NOFO is to solicit applications for the creation of a Validation Center to serve as a dedicated hub for the comprehensive evaluation and characterization of AI-enabled, image-based, multimodal CDS tools developed by the PRIMED-AI Consortium, to ensure these tools are reliable, reproducible, and generalizable. The Validation Center will focus on verification, validation, interoperability, and uncertainty quantification to comprehensively characterize performance of the CDS tools developed by the program. The core functions of the Validation Center will involve the systematic validation of PRIMED-AI Consortium deliverables, including those emerging from award recipients under the Playbook, Data-to-Model Academic-Industrial Partnerships, and Model-to-Clinic NOFOs.
Contact
National Institutes of Health · ODPRIMED-AI@od.nih.gov